The HPE ProLiant Compute DL380 Gen12 is a scalable 2U 2P server that delivers exceptional compute performance, memory density with scalability and high-speed data transfer rate to run your most demanding applications. Powered by Intel® Xeon® 6 processors with up to 144 cores and up to 8 TB of memory as well as 36 EDSFF E3.S drives, the HPE ProLiant Compute DL380 Gen12 is an ideal hybrid cloud platform for enterprise applications and workloads.
Are you looking for a two-socket scalable server that powers data analytics and supports hybrid cloud workloads?
The HPE ProLiant Compute DL380 Gen12 is a scalable 2U 2P server that delivers exceptional compute performance, memory density with scalability and high-speed data transfer rate to run your most demanding applications. Powered by Intel® Xeon® 6 processors with up to 144 cores and up to 8 TB of memory as well as 36 EDSFF E3.S drives, the HPE ProLiant Compute DL380 Gen12 is an ideal hybrid cloud platform for enterprise applications and workloads.
The HPE ProLiant Compute DL380 Gen12 is engineered for your future, with next-level security, optimized performance and efficiencies, and automated, AI-driven productivity.
What's new
• Intel® Xeon® 6 processors that support up to 144 cores, up to 8 TB of DDR5 memory at speeds up to 6400 MT/s, and up to 2x average higher performance for general compute versus previous generations.
• Optional front accessible boot device for quicker access.
• Choice of two cooling options — air cooling or direct liquid cooling (DLC) for performance and energy efficiency to support sustainability initiatives.
• Up to 36 EDSFF E3.S NVMe drives.
• Up to three double-wide (DW) or eight single-wide (SW) GPUs.
• HPE Integrated Lights-Out 7 (iLO 7) server management software with streamlined manageability through a redesigned GUI, Redfish API, and increased security via the patented secure enclave technology.



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MODEL |
HPE ProLiant Compute DL380 Gen12 |
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Processor family |
Intel® Xeon® 6 Scalable processors |
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Processor core available |
8 to 144 core, depending on processor |
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Processor cache |
2.5 MB to 112.5 MB L3, depending on processor |
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Processor number |
1 or 2 |
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Processor speed |
3.9 GHz maximum, depending on processor |
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Maximum memory |
8 TB with 256 GB DDR5 |
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Memory slots |
32 |
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Memory type |
HPE DDR5 Smart Memory |
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Memory protection features |
RAS – Advanced ECC, online spare, mirroring, combined channel (lockstep) functionality, and HPE Fast Fault Tolerant Memory (ADDDC) |
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Drive supported |
8 or 12 LFF SAS/SATA/SSD 8, 16, or 24 SFF SAS/SATA/SSD, depending on configuration. 6 SFF rear drive optional or or 2 SFF |
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Optical drive type |
Optional DVD-ROM Optional through Universal Media Bay External support only |
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Security |
HPE TPM 2.0 standard on motherboard. Optional locking Bezel Kit, Intrusion Detection Kit. |
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Infrastructure management |
HPE iLO Standard with intelligent provisioning (embedded), HPE OneView Standard (requires download) (standard) HPE iLO Advanced,HPE OneView Advanced (optional, requires licenses), and HPE Compute Ops Management |
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Power supply type |
800W, 1000W, 1600W or 1800W-2200W Dual hot-plug redundant 1+1 HPE Flexible Slot Power Supplies, depending on model |
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Expansion slots |
Up to 8 PCIe Gen5, and 2 OCP 3.0 (front or rear), for detailed descriptions reference the QuickSpecs |
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Network controller |
1 Gb, 10 Gb, 10/25 Gb, 100 Gb, or 200 Gb, in PCIe adapter or OCP 3.0 form factor, depending on model. For detailed descriptions |
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Storage controller |
HPE MR216i-o and/or MR216 i-p, HPE MR416i-o and/or HPE MR416i-p, HPE MR408e-p, HPE 408i-0 and/or HPE MR408i-p, depending on model. |
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System fan features |
Hot-plug redundant fans, Standard Fan Kit or High Performance Fan Kit, depending on model |
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Form factor |
2U Rack |